Research & Studies
Extensive research on Tier 2 -Tier 3 chambers provides valuable insights for those seeking reputable resources.
HBOT Mechanism
HBOT AND GENERAL HEALTH
Fife CE, Eckert KA, Carter MJ. An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg. 2016;138(3 Suppl):107S–16S. doi:10.1097/PRS.0000000000002714
Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008
Fujita N, Ono M, Tomioka T, et al. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One. 2014;9(12):e115685. Published 2014 Dec 22. doi:10.1371/journal.pone.0115685
Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025
Hink J, Jansen E. Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med. Hypotheses, 57 (6) (2001), pp. 764-769.
HBOT AND DEMENTIA/ALZHEIMER’S
Harch PG, Fogarty EF. Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report. Med Gas Res. 2019;8(4):181–184. Published 2019 Jan 9. doi:10.4103/2045-9912.248271
Shapira R, Efrati S, Ashery U. Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease. Neural Regen Res. 2018;13(5):817–818. doi:10.4103/1673-5374.232475
Qiang, Li Lan, Xiong Su-qin, Yan Yu-fen, Li Dan, Yan Na-na, Chen Hong-ping, Liu You-ping, Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia, Frontiers in Aging Neuroscience, VOLUME.11.2019 PAGES=86 DOI=10.3389/fnagi.2019.00086 ISSN=1663-4365
HBOT AND FIBROMYALGIA
Efrati S, Golan H, Bechor Y, et al. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome–prospective clinical trial. PLoS One. 2015;10(5):e0127012. Published 2015 May 26. doi:10.1371/journal.pone.0127012
Hadanny A, Bechor Y, Catalogna M, et al. Hyperbaric oxygen therapy can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse-randomized controlled trial. Front Psychol. 2018;9:2495. Published 2018 Dec 17. doi:10.3389/fpsyg.2018.02495
Efrati S, Hadanny A, Daphna-Tekoah S, et al. Recovery of repressed memories in fibromyalgia patients treated with hyperbaric oxygen – case series presentation and suggested bio-psycho-social mechanism. Front Psychol. 2018;9:848. Published 2018 May 29. doi:10.3389/fpsyg.2018.00848
Yildiz S, Kiralp MZ, Akin A, et al. A new treatment modality for fibromyalgia syndrome: hyperbaric oxygen therapy J. Int. Med. Res., 32 (3) (2004), pp. 263-267
HBOT AND AUTISM
Rossignol DA, Bradstreet JJ, Van Dyke K, et al. Hyperbaric oxygen treatment in autism spectrum disorders. Med Gas Res. 2012;2(1):16. Published 2012 Jun 15. doi:10.1186/2045-9912-2-16
Rossignol DA, Rossignol LW, Smith S, et al. Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial [published correction appears in BMC Pediatr. 2012 Dec;42(4):236]. BMC Pediatr. 2009;9:21. Published 2009 Mar 13. doi:10.1186/1471-2431-9-21
Xiong T, Chen H, Luo R, et al. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). Cochrane Database Syst Rev. 2016;10(10):CD010922. Published 2016 Oct 13. doi:10.1002/14651858.CD010922.pub2
Rossignol DA, Bradstreet JJ, Van Dyke K, et al. Hyperbaric oxygen treatment in autism spectrum disorders. Med Gas Res. 2012;2(1):16. Published 2012 Jun 15. doi:10.1186/20
45-9912-2-16
Rossignol DA, Rossignol LW. Hyperbaric oxygen therapy may improve symptoms in autistic children. Medical Hypotheses, Volume 67, Issue 2, 2006, Pages 216-228, ISSN 0306-9877, https://doi.org/
10.1016/j.mehy.2006.02.009.
Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Frontiers in Physiology. 5 2014.
pgs.150. https://www.frontiersin.org
/article/10.3389/fph
ys.2014.00150 DOI=10.3389/fphys.2014.00150
HBOT AND INFECTION
Çimşit M, Uzun G, & Yıldız S (2009) Hyperbaric oxygen therapy as an anti-infective agent. Expert Review of Anti-infective Therapy, 7:8, 1015-1026, DOI: 10.1586/eri.09.76
Ezra N, Dang K, Heuser G. Improvement of attention span and reaction time with hyperbaric oxygen treatment in patients with toxic injury due to mold exposure. Eur J Clin Microbiol Infect Dis. 2011;30(1):1–6. doi:10.1007/s10096-010-0937-8
Mader JT, Brown GL, Guckian JC, et al. A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits. J Infect Dis. 1980 Dec. 142(6):915-22
Delasotta LA, Hanflik A, Bicking G, et al. Hyperbaric oxygen for osteomyelitis in a compromised host. Open Orthop J. 2013;7:114–117. Published 2013 May 3. doi:10.2174/1874325001307010114
Ciofu O, Tolker-Nielsen T. Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents-how P. aeruginosa can escape antibiotics. Front Microbiol. 2019;10:913. Published 2019 May 3. doi:10.3389/fmicb.2019.00913
Kolpen M, Lerche CJ, Kragh KN, et al. Hyperbaric oxygen sensitizes anoxic pseudomonas aeruginosa biofilm to ciprofloxacin. Antimicrob Agents Chemother. 2017;61(11):e01024-17. Published 2017 Oct 24. doi:10.1128/AAC.01024-17
Gade PAV, Olsen TB, Jensen PØ, et al. Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen treatment in Pseudomonas aeruginosa PAO1 biofilms. PLoS ONE (2018): e0198909. https://doi.org/10.
1371/journal.pone.0198909
Memar MY, Yekani M, Alizadeh N, et al. Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections. Biomedicine & Pharmacotherapy, Volume 109, 2019, Pages 440-447, ISSN 0753-3322, https://doi.org/10.
1016/j.biopha.2018.10.142.
Kaye D. Effect of hyperbaric oxygen on Clostridia in vitro and in vivo. Proc Soc Exp Biol Med 1967; 124:360.
HBOT AND CANCER (AND KETO)
İyikesici M, Slocum A, Slocum A, et al. (July 07, 2017) Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV TripleNegative Breast Cancer. Cureus 9(7): e1445. DOI 10.7759/cureus.1445
Poff AM, Ari C, Seyfried TN, et al. (2013) The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS ONE 8(6): e65522. https://doi.org/10.1371/journ
al.pone.0065522
Seyfried, TN, Mukherjee, P. Nutr Metab (Lond) (2005) 2: 30. https://doi.org/10.1186/1743-7075-2-30
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029–1033. doi:10.1126/science.1160809
CANCER (HBOT ONLY)
Moen I, Stuhr LE. Hyperbaric oxygen therapy and cancer–a review. Target Oncol. 2012;7(4):233–242. doi:10.1007/s11523-012-0233-x
Thom SR, Bhopale VM, Yang M. Microparticle-induced vascular injury in mice following decompression is inhibited by hyperbaric oxygen: effects on microparticles and interleukin-1.
Journal of Applied Physiology, Volume 126, 2019
Niezgoda JA, Serena TE, Carter MJ. Outcomes of radiation injuries using hyperbaric oxygen therapy: an observational cohort study. Adv Skin Wound Care, 29 (2016), pp. 12-1
Stępień K, Ostrowski RP, Matyja E. Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours. Med Oncol. 2016;33(9):101. doi:10.1007/s12032-016-0814-0
Oscarsson N, Ny L, Mölne J, Lind F, et al. Hyperbaric oxygen treatment reverses radiation induced pro-fibrotic and oxidative stress responses in a rat model. Free Radic Biol Med. 2017 Feb; 103:248-255. Epub 2016 Dec 27
Zembrzuska K, Ostrowski RP, Matyja E. Hyperbaric oxygen increases glioma cell sensitivity to antitumor treatment with a novel isothiourea derivative in vitro. Oncol Rep. 2019;41(5):2703–2716. doi:10.3892/or.2019.7064
Lu QZ, Li X, Ouyang J, et al. Further application of hyperbaric oxygen in prostate cancer. Med Gas Res. 2019;8(4):167–171. Published 2019 Jan 9. doi:10.4103/2045-9912.248268
Wang YG, Long J, Shao DC, et al. Hyperbaric oxygen inhibits production of CD3+ T cells in the thymus and facilitates malignant glioma cell growth. J Int Med Res. 2018;46(7):2780–2791. doi:10.1177/0300060518767796
Choudhury R. Hypoxia and hyperbaric oxygen therapy: a review. Int J Gen Med. 2018;11:431–442. Published 2018 Nov 20. doi:10.2147/IJGM.S172460
Yahara K, Ohguri T, Udono H, et al. Radiotherapy using IMRT boosts after hyperbaric oxygen therapy with chemotherapy for glioblastoma. J Radiat Res. 2017;58(3):351–356. doi:10.1093/jrr/rrw105
HBOT AND WOUND HEALING
Health Quality Ontario. Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment. Ont Health Technol Assess Ser. 2017;17(5):1–142. Published 2017 May 12.
Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012;45(2):316–324. doi:10.4103/0970-0358.101309
Hou S, Wu G, Liang J, et al. Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels. Oncol Lett. 2019;17(3):3277–3282. doi:10.3892/ol.2019.10000
Perren S, Gatt A, Papanas N, et al. Hyperbaric oxygen therapy in ischaemic foot ulcers in type 2 diabetes: a clinical trial. Open Cardiovasc Med J. 2018;12:80–85. Published 2018 Aug 31. doi:10.2174/1874192401812010080
Eskes AM, Ubbink DT, Lubbers MJ, et al. Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review. World J Surg. 2011;35(3):535–542. doi:10.1007/s00268-010-0923-4
HBOT AND TBI/CONCUSSION
Boussi-Gross R, Golan H, Fishlev G, et al. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury – randomized prospective trial. PLoS One. 2013;8(11):e79995. Published 2013 Nov 15. doi:10.1371/journal.pone.0079995
Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508
Meng XE, Zhang Y, Li N, et al. Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of tlr4/nf-κb signaling pathway. Med Sci Monit. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148
Vlodavsky, E. Palzur, M. Feinsod, et al. Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral contusion, treated by hyperbaric oxygen therapy: a quantitative immunohistochemical study. Acta Neuropathol., 110 (2) (2005), pp. 120-126
Hadanny A, Abbott S, Suzin G, et al. Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open. 2018;8(9):e023387. Published 2018 Sep 28. doi:10.1136/bmjopen-2018-023387
Dong Y, Hu XH, Wu T, et al. Effect of hyperbaric oxygenation therapy on post-concussion syndrome [published correction appears in Exp Ther Med. 2018 Dec;16(6):4918]. Exp Ther Med. 2018;16(3):2193–2202. doi:10.3892/etm.2018.6463
Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508
Tsutsumi I, Tsujimoto Y, Takahashi S, et al. Hyperbaric oxygen therapy for persistent post‐concussion syndrome following mild traumatic brain injury. Cochrane Database Syst Rev. 2017;2017(7):CD012727. Published 2017 Jul 16. doi:10.1002/14651858.CD012727
Eve DJ, Steele MR, Sanberg PR, et al. Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Treat. 2016;12:2689–2705. Published 2016 Oct 20. doi:10.2147/NDT.S110126
HBOT AND STROKE
Rosario ER, Kaplan SE, Khonsari S, et al. The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke. Neurol Res Int. 2018;2018:3172679. Published 2018 Oct 9. doi:10.1155/2018/3172679
Ostrowski RP, Stępień K, Pucko E, Matyja E. The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications. Arch Med Sci. 2017;13(5):1217–1223. doi:10.5114/aoms.2017.65081
Efrati, G. Fishlev, Y. Bechor, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients–randomized, prospective trial. PLoS One, 8 (1) (2013
Liska GM, Lippert T, Russo E, et al. A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells. Cond Med. 2018;1(4):151–166.
Efrati S, Fishlev G, Bechor Y, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients–randomized, prospective trial. PLoS One. ;8(1):e53716. doi:10.1371/journal.pone.0053716
Hadanny A, Efrati S. Oxygen–a limiting factor for brain recovery. Crit Care. 2015;19(1):307. Published 2015 Sep 1. doi:10.1186/s13054-015-1034-2
Hadanny A, Golan H, Fishlev G, et al. Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage. Restor Neurol Neurosci. ;33(4):471–486. doi:10.3233/RNN-150517
HBOT AND STEM CELLS
Thom SR, Bhopale VM, Velazquez OC, et al. Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology-Heart and Circulatory Physiology 2006 290:4, H1378-H1386
Oyaizu T, Enomoto M, Yamamoto N, et al. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018;8(1):1288. Published 2018 Jan 22. doi:10.1038/s41598-018-19670-x
Liska GM, Lippert T, Russo E, et al. A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells. Cond Med. 2018;1(4):151–166.
Peña-Villalobos I, Casanova-Maldonado I, Lois P, et al. Hyperbaric oxygen increases stem cell proliferation, angiogenesis and wound-healing ability of WJ-MSCs in diabetic mice. Front Physiol. 2018;9:995. Published 2018 Jul 30. doi:10.3389/fphys.2018.00995
Fosen KM, Thom SR. Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal. 2014;21(11):1634–1647. doi:10.1089/ars.2014.5940
Milovanova TN, Bhopale VM, Sorokina EM, et al. Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo. J Appl Physiol (1985). 2009;106(2):711–728. doi:10.1152/japplphysiol.91054.2008
MacLaughlin KJ, Barton GP, Braun RK, Eldridge MW. Effect of intermittent hyperoxia on stem cell mobilization and cytokine expression. Med Gas Res. 2019;9(3):139–144. doi:10.4103/2045-9912.266989
HBOT AND PTSD
Eve DJ, Steele MR, Sanberg PR, et al. Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Treat. 2016;12:2689–2705. Published 2016 Oct 20.doi:10.2147/NDT.S110126
Harch PG, Andrews SR, Fogarty EF, et al. Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder. Med Gas Res. 2017;7(3):156–174. Published 2017 Oct 17. doi:10.4103/2045-9912.215745
He H, Li X, He Y. Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway. Neuropsychiatr Dis Treat. 2019;15:369–374. Published 2019 Jan 25. doi:10.2147/NDT.S183632
HBOT AND OTHER NEUROLOGICAL ISSUES
Nazario J, Kuffler DP. Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma. Undersea Hyperb Med. 2011 Sep-Oct;38(5):345-66. Review. PubMed PMID: 22013761
Hu Q, Manaenko A, Xu T, et al. Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside. Med Gas Res. 2016;6(2):102–110. Published 2016 Jul 11. doi:10.4103/2045-9912.184720
Taghizadeh Asl M, Nemati R, Chabi N, et al. Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce. BMC Neurol. 2016;16:79. Published 2016 May 26. doi:10.1186/s12883-016-0605-4
M.Z. Kiralp, Ş Yildiz, D. Vural, et al. Effectiveness of hyperbaric oxygen therapy in the treatment of complex regional pain syndrome. J. Int. Med. Res., 32 (3) (2004), pp. 258-262.
Oroglu B, Turker T, Aktas S, et al. Effect of hyperbaric oxygen therapy on tense repair of the peripheral nerves. Undersea Hyperb Med. 2011 Sep-Oct; 38(5): 367–373.
Hadanny A, Efrati S. Oxygen–a limiting factor for brain recovery. Crit Care. 2015;19(1):307. Published 2015 Sep 1. doi:10.1186/s13054-015-1034-2
Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025
Hadanny A, Maliar A, Fishlev G, et al. Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. Clin Ophthalmol. 2016;11:115–125. Published 2016 Dec 29. doi:10.2147/OPTH.S121307
Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508
HBOT AND MITOCHONDRIA
Palzur E, Zaaroor M, Vlodavsky E, et al. Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain Res., 1221 (2008), pp. 126-133
K.R. Dave, R. Prado, R. Busto, A.P. Raval, W.G. Bradley, D. Torbati, M.A. Pérez-pinzón,
Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in wobbler mice, Neuroscience, Volume 120, Issue 1, 2003, Pages 113-120,
ISSN 0306-4522, https://doi.org/10.1016/S0306-4522(03)00244-6.
Meyer JN, Hartman JH, Mello DF. Mitochondrial toxicity. Toxicological Sciences, Volume 162, Issue 1, March 2018, Pages 15–23.
Meyer JN, Leung MC, Rooney JP, et al. Mitochondria as a target of environmental toxicants. Toxicol Sci. 2013;134(1):1–17. doi:10.1093/toxsci/kft102
HBOT AND MICROBIOME
Schmidt TM, Kao JY. A little O2 may go a long way in structuring the GI microbiome. Gastroenterology. 2014;147(5):956–959. doi:10.1053/j.gastro.2014.09.025
Nyabanga CT, Kulkarni G, Shen B. Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis. Gastroenterology Report, Volume 5, Issue 4, November 2017, Pages 320–321, https://doi.org/10.1093/gas
tro/gov038
Albenberg L, Esipova TV, Judge CP, et al. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology, Volume 147, Issue 5,2014,Pages 1055-1063.e8,ISSN 0016-5085, https://doi.org/10.1
053/j.gastro.2014.07.020.
Crabbé A, Jensen PO, Bjarnsholt T, et al. Antimicrobial tolerance and metabolic adaptations in microbial biofilms. Trends in Microbiology. Volume 27, Issue 10, 2019, Pages 850-863, ISSN 0966-842X, https://doi.org/10.1016/j.
tim.2019.05.003.
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